Leafy Poultice

Leafy Poultice is a Boss relic in Slay the Spire 2 that applies 1 Vulnerable to all enemies at the start of each combat. This opening debuff ensures that your first turn of attacks deals 50% more damage to every enemy on the field, giving you an immediate offensive advantage.

Starting each fight with enemies already Vulnerable is a powerful benefit that lets you deal enhanced damage before spending any cards or Energy on debuff application. This is especially impactful in the early turns when you are racing to kill enemies before they can ramp up their damage or deploy dangerous buffs.

Leafy Poultice synergizes strongly with Paper Phrog, which increases the Vulnerable damage bonus from 50% to 75%. It pairs well with front-loaded Attack strategies and multi-hit cards that multiply the damage bonus across each hit. The relic is less impactful in builds that already apply Vulnerable consistently through cards like Bash or Leg Sweep, as the redundancy reduces its relative value. For decks that prioritize raw damage output, Leafy Poultice provides a reliable combat opener that accelerates your kill speed.