Slay the Spire 2 Wiki

Card

Debilitate

Deal 7 damage. Vulnerable and Weak are twice as effective against the enemy for 3 turns.

Debilitate is an uncommon Necrobinder attack costing 1 Energy that deals 7 damage and makes Weak and Vulnerable twice as effective against the target for 3 turns. This debuff amplifier transforms standard debuffs into devastating multipliers, doubling the damage reduction from Weak and the damage increase from Vulnerable.

Debilitate is the perfect setup for Putrefy, whose 2 Weak and 2 Vulnerable effectively become 4 each. Enfeebling Touch's Strength reduction pairs well with the doubled Weak. Misery spreads the amplified debuff state to all enemies, and Sleight of Flesh triggers damage from the debuff applications Debilitate enables.

In the Necrobinder Doom archetype and beyond, Debilitate transforms your debuff cards into overwhelming control. Against bosses like Vantom and Kin Priest who deal heavy damage, doubled Weak dramatically reduces incoming damage. Against any boss, doubled Vulnerable makes your Attacks and Doom execution far more lethal. The 3-turn duration means one Debilitate creates a sustained window of amplified debuffs.

Details

Card TypeAttack
Cost1
RarityUncommon
TargetSingle-Enemy
Effect TextDeal 7 Damage. Vulnerable And Weak Are Twice As Effective Against The Enemy For 3 Turns.

Character

NoindexYes
In GameConfirmed

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Quick Facts

Type
Card
Confidence
Medium
Verified
Mar 12, 2026