Slay the Spire 2 Wiki

Card

Malaise

Enemy loses X Strength. Apply X Weak. Exhaust.

Malaise is an X-cost rare Skill card for the Silent that causes an enemy to lose X Strength and applies X Weak. Spending all your energy on Malaise can completely neutralize a dangerous enemy's offense for multiple turns. The Strength reduction is permanent, while the Weak wears off over time.

Malaise pairs with Adrenaline for extra energy to maximize the X value. Leg Sweep layers additional Weak on top of Malaise's application. Neutralize provides free Weak that stacks with Malaise. Burst doubles Malaise for twice the Strength loss and Weak application, which can completely shut down enemy offense.

Silent players should pick Malaise against bosses with high Strength like Ceremonial Beast and The Insatiable where Strength removal is critical. It is less effective against enemies that rely on non-attack abilities. The X-cost means it scales with energy, so pair it with Adrenaline and Accelerant for maximum debuff potency.

Details

Card TypeSkill
RarityRare
TargetSingle-Enemy
Effect TextEnemy Loses X Strength. Apply X Weak. Exhaust.

Character

NoindexYes
In GameConfirmed

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Quick Facts

Type
Card
Confidence
High
Verified
Mar 12, 2026