Slay the Spire 2 Wiki

Card

Neutralize

Deal 3 damage. Apply 1 Weak.

Neutralize is a 0-cost common Attack starter card for the Silent that deals 3 damage and applies 1 Weak to an enemy. As the Silent's starting card, it provides a free source of the Weak debuff, reducing enemy damage by 25%. The zero cost means it never competes with other cards for energy.

Neutralize pairs with Leg Sweep for layering additional Weak to keep enemies permanently debuffed. Envenom adds Poison whenever Neutralize's damage is unblocked, bridging into Poison strategies. Finisher counts Neutralize as an Attack played, and Follow Through draws cards when it is among multiple Attacks played. Expose builds on the debuff theme by adding Vulnerable on top of Weak.

Silent players start every run with Neutralize, and it remains useful throughout the game for free Weak application. It is effective against every boss in the game, from Ceremonial Beast in Act 1 to Doormaker in Act 3. The card is rarely removed from the deck because free Weak is always valuable, unlike Strike which loses relevance quickly.

Details

Card TypeAttack
Cost0
RarityCommon
TargetSingle-Enemy
Effect TextDeal 3 Damage. Apply 1 Weak.

Character

NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Card
Game Version
Early Access (March 2026)
Confidence
Medium
Verified
Mar 12, 2026

Sources

slaythespire.wiki.gg; PCGamesN character guide

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