Slay the Spire 2 Wiki

Card

Envenom

Whenever an Attack deals unblocked damage, apply 1 Poison.

Envenom is a 2-cost rare Power card for the Silent that causes every instance of unblocked Attack damage to apply 1 Poison. Once in play, every Attack card becomes a Poison applicator, turning even small hits into sources of lasting damage. This passive effect stacks with existing Poison from other sources, creating a multiplicative damage engine.

Envenom pairs exceptionally well with Dagger Spray, which hits ALL enemies twice and applies Poison to each hit. Ricochet's three random hits each apply Poison, making it an efficient applicator. Blade Dance and the Shiv archetype become Poison engines with Envenom active, as each Shiv applies Poison alongside its direct damage. Accuracy amplifies this further by boosting Shiv damage so more hits land unblocked.

Silent players should pick Envenom when their deck already has many multi-hit or cheap Attack cards. It excels against bosses like Kaiser Crab and Test Subject #C10 where sustained pressure is valuable. The 2-energy cost is steep, so ensure you have energy generation from cards like Adrenaline or relics before committing to this Power.

Details

Card TypePower
Cost2
RarityRare
TargetSelf
Effect TextWhenever An Attack Deals Unblocked Damage, Apply 1 Poison.

Character

NoindexYes
In GameConfirmed

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Quick Facts

Type
Card
Confidence
High
Verified
Mar 12, 2026