Slay the Spire 2 Wiki

Card

Noxious Fumes

At the start of your turn, apply 2 Poison to ALL enemies.

Noxious Fumes is a 1-cost uncommon Power card for the Silent that applies 2 Poison to ALL enemies at the start of each turn. Because it triggers automatically every turn without costing any further cards or energy, it provides steadily accumulating damage that grows more lethal as fights drag on. Against multiple enemies, it poisons the entire field simultaneously, making it one of the most efficient sources of sustained area damage in the Silent's kit.

Noxious Fumes synergizes powerfully with Outbreak, which adds 1 additional Poison each time Poison damages an enemy, causing exponential Poison growth. Bouncing Flask front-loads Poison stacks that Noxious Fumes then amplifies each turn. Corpse Explosion pairs well by converting the massive Poison damage into area-of-effect when an enemy dies. Leg Sweep provides the Weak and Block needed to survive while waiting for Poison to finish enemies off.

Silent players should prioritize Noxious Fumes in Poison-focused builds, especially for long boss fights against Ceremonial Beast and Knowledge Demon where sustained damage outperforms burst. It is less effective in short hallway fights where enemies die before Poison accumulates. Pick this card early when committing to a Poison archetype, as it defines the pacing of the entire deck.

Details

Card TypePower
Cost1
RarityUncommon
TargetAll-Enemies
Effect TextAt The Start Of Your Turn, Apply 2 Poison To ALL Enemies.

Character

NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Card
Confidence
High
Verified
Mar 12, 2026