Slay the Spire 2 Wiki

Card

Outbreak

Every 3 times you apply Poison, deal 11 damage to ALL enemies.

Outbreak is a 1-cost uncommon Power card for the Silent that causes an additional 1 Poison to be applied whenever Poison damages an enemy. This means every time an enemy takes their Poison tick at the start of their turn, they gain 1 more Poison, causing the stacks to grow rather than simply shrink. Over multiple turns, this creates exponential Poison growth.

Outbreak is the defining amplifier for Poison strategies, pairing exceptionally with Noxious Fumes to create ever-growing Poison stacks each turn. Bouncing Flask and Deadly Poison provide the initial Poison stacks that Outbreak then amplifies. Corrosive Wave's area Poison application combined with Outbreak means every poisoned enemy's stacks keep growing. Multiple copies of Outbreak stack, adding even more Poison per tick.

Silent players building around Poison should consider Outbreak a top priority pickup, as it transforms linear Poison into exponential scaling. It is most valuable in long boss fights against Knowledge Demon, Doormaker, and Test Subject #C10 where the exponential growth has time to become lethal. Pick this early when you see Noxious Fumes or other reliable Poison sources in your deck.

Details

Card TypePower
Cost1
RarityUncommon
TargetAll-Enemies
Effect TextEvery 3 Times You Apply Poison, Deal 11 Damage To ALL Enemies.

Character

NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Card
Confidence
High
Verified
Mar 12, 2026