Slay the Spire 2 Wiki

Potion

Blood Potion

Heal 2 HP for each Exhausted card this combat.

Blood Potion restores a portion of your current missing HP, healing more when you are at lower health. This reactive healing potion rewards risky play by providing larger heals when you are in the most danger, making it an excellent emergency recovery tool during combat.

Blood Potion is most effective when used at low HP during grueling boss fights against The Insatiable or Vantom, where you intentionally delay drinking it to maximize healing value. It is also strong against Doormaker when chip damage accumulates and you need to recover without spending energy on healing cards.

Ironclad is the ideal Blood Potion user, combining it with Offering's HP cost for a larger heal and Brutality's per-turn damage for sustained low-HP strategies. Reaper provides additional lifesteal, and Rupture gains Strength from HP loss, making the blood-themed synergy complete. Burning Blood heals at end of combat to complement mid-combat Blood Potion healing. Necrobinder benefits from healing after self-damage from Forbidden Grimoire. Sacred Bark doubles the healing percentage, and Toy Ornithopter adds its healing on top. White Beast Statue helps maintain your potion supply.

Details

Potion RarityCommon
EffectHeal 2 HP For Each Exhausted Card This Combat.
NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Potion
Game Version
Early Access (March 2026)
Confidence
Medium
Verified
Mar 12, 2026

Sources

slaythespire.wiki.gg; untapped.gg/en/potions