Slay the Spire 2 Wiki

Potion

Cure All

Gain 1 Colorless Energy. Draw 2 cards.

Cure All removes all debuffs currently applied to your character, cleansing negative effects like Weak, Vulnerable, Frail, and other harmful statuses. This potion acts as a full reset of your debuff state, letting you return to full combat effectiveness in a single action without spending energy.

Cure All is invaluable against Knowledge Demon, whose mechanics rely heavily on stacking debuffs to cripple your output. It is also critical in the Lagavulin Matriarch fight, where persistent Strength and Dexterity reductions can render your cards ineffective if left unchecked.

Silent benefits most from Cure All when running Wraith Form, since the Dexterity loss from Wraith Form's expiration can be cleansed. Ironclad players using Brutality appreciate the debuff removal to stay healthy. The Defect can pair it with Biased Cognition to remove the Focus loss after gaining the initial boost. Toy Ornithopter adds healing on top of the cleanse, and Sacred Bark has no additional effect since this potion does not scale with numbers.

Details

Potion RarityUncommon
EffectGain 1 Colorless Energy. Draw 2 Cards.
NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Potion
Confidence
High
Verified
Mar 12, 2026

Sources

slaythespire.wiki.gg/wiki/Potions_List_(Slay_the_Spire_2)