Slay the Spire 2 Wiki

Potion

Strength Potion

Gain 2 Strength.

Strength Potion grants permanent Strength for the rest of combat, increasing the damage of every attack card you play. Unlike Flex Potion, this Strength does not expire at end of turn, making it a true scaling tool that grows in value the longer the fight continues.

Drink Strength Potion early in long boss fights against Soul Fysh or Kin Priest to maximize the cumulative damage bonus across many turns. It is less valuable in short hallway fights where the fight ends before the Strength investment pays off compared to direct damage potions.

Ironclad is the premier Strength Potion user, stacking it with Demon Form for rapid Strength scaling and amplifying Reaper's lifesteal proportionally. Heavy Strike and Fiend Fire deal enormous damage with added Strength. Silent can pair it with Blade Dance for multiple Strength-boosted shivs. Sacred Bark doubles the Strength granted, and Toy Ornithopter provides healing on potion use. Sozu prevents finding more potions, so drink Strength Potion early if you acquire it alongside that relic.

Details

Potion RarityCommon
EffectGain 2 Strength.
NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Potion
Confidence
High
Verified
Mar 12, 2026

Sources

slaythespire.wiki.gg/wiki/Potions_List_(Slay_the_Spire_2)