Slay the Spire 2 Wiki

Potion

Vulnerable Potion

Apply 3 Vulnerable.

Vulnerable Potion applies Vulnerable to a target enemy, causing them to take 50 percent more damage from attacks for several turns. This offensive potion amplifies all your attack damage without costing energy, making it one of the most efficient damage multipliers available.

Use Vulnerable Potion at the start of critical boss fights like Vantom or The Insatiable to maximize your damage output during your burst window. It is also strong against Test Subject #C10 when you need to push through a large HP pool as quickly as possible.

Ironclad maximizes Vulnerable Potion with Immolate and Fiend Fire for massive amplified damage in a single turn. Silent can combine it with Blade Dance for multiple Vulnerable-boosted hits. Defect pairs it with Electrodynamics to spread amplified Lightning damage across all enemies. Sacred Bark extends the Vulnerable duration for sustained damage amplification. Burning Blood provides passive healing for Ironclad to complement offensive potion usage, keeping your HP healthy while you focus on damage.

Details

Potion RarityCommon
EffectApply 3 Vulnerable.
NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Potion
Confidence
High
Verified
Mar 12, 2026

Sources

slaythespire.wiki.gg/wiki/Potions_List_(Slay_the_Spire_2)