Slay the Spire 2 Wiki

Card

Assassinate

Innate. Deal 10 damage. Apply 1 Vulnerable. Exhaust.

Assassinate is a 2-cost rare Attack card for the Silent that deals 15 damage, and if the enemy is below half HP, the damage is tripled to 45. This execute effect makes it devastating against wounded enemies, delivering a finishing blow that can end fights instantly. The condition rewards Poison and chip damage strategies that reduce enemy HP before the killing blow.

Assassinate pairs excellently with Noxious Fumes and Poison cards that whittle enemies below half HP for the triple damage. Envenom adds Poison while dealing Attack damage, helping reach the threshold. Neutralize and Expose apply Weak and Vulnerable to soften enemies faster. Finisher can be played alongside Assassinate in Attack-heavy turns for massive total damage.

Silent players should pick Assassinate in builds with reliable damage sources that can reduce enemies below half HP. It excels as a finisher against bosses like Ceremonial Beast and Soul Fysh. The 2-cost means timing is critical, so use Well-Laid Plans to Retain it until the enemy crosses the HP threshold.

Details

Card TypeAttack
Cost0
RarityRare
TargetSingle-Enemy
Effect TextInnate. Deal 10 Damage. Apply 1 Vulnerable. Exhaust.

Character

NoindexNo
In GameConfirmed

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Quick Facts

Type
Card
Confidence
High
Verified
Mar 12, 2026