Potion
Explosive Ampoule
Deal 10 damage to ALL enemies.
Explosive Ampoule deals heavy damage to all enemies on the field, functioning as a free area-of-effect nuke. This potion excels in multi-enemy encounters where spreading damage across all targets simultaneously saves you multiple turns of individual attacks.
Explosive Ampoule is devastating against multi-enemy elite fights and is particularly effective against Soul Fysh and its summoned minions. Save it for encounters with Doormaker where clearing multiple threats quickly prevents the fight from spiraling out of control.
Ironclad pairs Explosive Ampoule with Immolate for layered AoE damage that can wipe entire encounters. Defect can combine it with Electrodynamics for comprehensive multi-target coverage. Silent benefits less from AoE but can use it alongside Noxious Fumes to finish poisoned enemies simultaneously. Necrobinder can follow up with Oblivion for massive board-wide destruction. Sacred Bark doubles the damage for devastating results, and Toy Ornithopter heals on use. Sozu prevents future potion drops, so use Explosive Ampoule liberally if you carry that relic.
Details
Guides & Articles
Quick Facts
- Type
- Potion
- Confidence
- High
- Verified
- Mar 12, 2026
Sources
slaythespire.wiki.gg/wiki/Potions_List_(Slay_the_Spire_2)\nsts2.untapped.gg/en/potions
