Slay the Spire 2 Wiki

Potion

Fire Potion

Deal 20 damage.

Fire Potion deals a fixed amount of direct damage to a single enemy without requiring energy or a card play. This straightforward offensive potion is useful for finishing off weakened enemies, sniping priority targets in multi-enemy fights, or supplementing your damage in key turns.

Fire Potion is effective for finishing off Kaiser Crab before its defensive mechanics activate, or for dealing damage to Kin Priest's minions while focusing your card plays on the main threat. It is also useful against Test Subject #C10 to push through the final stretch of its large HP pool.

Ironclad can combine Fire Potion's damage with Vulnerable Potion for amplified output, and Reaper does not interact with potion damage but can follow up for lifesteal. Silent appreciates Fire Potion alongside Envenom for applying Poison on top of direct damage. Defect can use it to finish enemies weakened by Electrodynamics' Lightning splash. Sacred Bark doubles the damage dealt, making it a serious burst tool. Toy Ornithopter heals on potion use, and White Beast Statue helps maintain your potion supply.

Details

Potion RarityCommon
EffectDeal 20 Damage.
NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Potion
Confidence
High
Verified
Mar 12, 2026

Sources

slaythespire.wiki.gg/wiki/Potions_List_(Slay_the_Spire_2)\nsts2.untapped.gg/en/potions