Slay the Spire 2 Wiki

Potion

Potion of Doom

Apply 3 Doom to a target enemy.

Potion of Doom unleashes devastating dark energy that deals massive damage to a single target, functioning as one of the highest single-target damage potions available. This potion serves as a finisher or burst damage tool for eliminating priority threats in a single action.

Save Potion of Doom for critical moments against bosses like Vantom or The Insatiable, where a massive damage spike can skip dangerous phases or secure the kill before the fight spirals. It is also effective against Kaiser Crab to burst through its defensive mechanics before they activate.

Necrobinder pairs Potion of Doom with Oblivion and Time's Up for a theme of overwhelming destructive force. Ironclad can combine it with Vulnerable Potion and Fiend Fire for layered burst damage. Silent can set up with Malaise to weaken the target before finishing with Potion of Doom. Defect can follow up with Hyperbeam for combined massive damage. Sacred Bark doubles the damage for a truly catastrophic single hit, and Toy Ornithopter heals when you drink it. Burning Blood helps Ironclad recover after aggressive potion usage.

Details

Potion RarityCommon
NoindexYes
EffectApply 3 Doom To A Target Enemy.
In GameConfirmed

Guides & Articles

Quick Facts

Type
Potion
Game Version
Early Access (March 2026)
Confidence
Low
Verified
Mar 12, 2026

Sources

slaythespire.wiki.gg; untapped.gg/en/potions