Slay the Spire 2 Wiki

Card

Snakebite

Retain. Apply 7 Poison.

Snakebite is a 1-cost common Skill card for the Silent that applies 2 Poison and 1 Weak to an enemy. The combination of Poison and Weak in a single cheap card makes it an efficient debuff applicator. Weak reduces enemy attack damage by 25%, providing meaningful defense while Poison chips away at health over time.

Snakebite pairs well with Noxious Fumes for layering Poison from multiple sources, and Outbreak amplifies the Poison stacks applied. Leg Sweep complements it with additional Weak application and heavy Block. Neutralize serves a similar role as the starter card, and together they keep enemies permanently Weakened. Envenom can add extra Poison if Snakebite's damage component lands unblocked.

Silent players should consider Snakebite in Poison builds that also want Weak uptime for defensive consistency. It is valuable against hard-hitting enemies like Ceremonial Beast and Kaiser Crab where Weak significantly reduces incoming damage. The card remains useful throughout the entire run due to the Weak application, even as raw Poison numbers become less impactful.

Details

Card TypeSkill
Cost2
RarityCommon
TargetSingle-Enemy
Effect TextRetain. Apply 7 Poison.

Character

NoindexNo
In GameConfirmed

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Quick Facts

Type
Card
Confidence
High
Verified
Mar 12, 2026