Slay the Spire 2 Wiki

Potion

Entropic Brew

Fill all your empty potion slots with random potions.

Entropic Brew fills all your empty potion slots with random potions, converting a single potion use into multiple diverse potion options. This meta-potion is one of the most valuable potions in the game because it generates additional resources, effectively multiplying your potion capacity.

Use Entropic Brew when you have the most empty potion slots to maximize the number of random potions generated. It is best consumed before major boss fights like Doormaker or Ceremonial Beast to stock up on diverse tools for the challenging encounters ahead.

All characters benefit equally from Entropic Brew since the random potions generated span the full potion pool. Ironclad might receive Strength or Fire Potions to complement Demon Form scaling. Silent could find Ghost in a Jar or Cunning Potion to enhance Wraith Form and Afterimage strategies. Defect may discover Focus Potion for orb scaling. Sacred Bark doubles the effect of every generated potion, creating enormous compound value. Sozu prevents potion drops entirely, making Entropic Brew extraordinarily valuable if you somehow acquire it. White Beast Statue is redundant if you have Entropic Brew.

Details

Potion RarityUncommon
EffectFill All Your Empty Potion Slots With Random Potions.
NoindexYes
In GameConfirmed

Guides & Articles

Quick Facts

Type
Potion
Game Version
Early Access (March 2026)
Confidence
Medium
Verified
Mar 12, 2026

Sources

slaythespire.wiki.gg; untapped.gg/en/potions